Regulation FD Disclosure. On August 4, 2026, Certara, Inc. (the “Company”) hosted its second quarter 2026 earnings conference call and posted on its website its second quarter 2026 earnings presentation. On the earnings conference call, there was a misstatement in the spoken reference to the 2025 adjusted EBITDA generated by the Company’s recently divested Regulatory and Medical Writing business, which was quoted as having “generated approximately $17 million of adjusted EBITDA in 2025 exclud…

President, Chief Commercial Officer — Leif E. Pedersen: Mr. Pedersen departed from his role as President, Chief Commercial Officer.

Results of Operations and Financial Condition. On August 4, 2026 , Certara, Inc. (the “Company”) issued a press release announcing its financial results for the three-month period ended June 30, 2026. A copy of the press release containing the announcement is attached hereto as Exhibit 99.1 and is incorporated herein by reference. The information furnished pursuant to this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act…

Chief Financial Officer — John E. Gallagher III: Mr. Gallagher resigned to pursue another opportunity.

Results of Operations and Financial Condition. On May 11, 2026 , Certara, Inc. (the “Company”) issued a press release announcing its financial results for the three-month period ended March 31, 2026. A copy of the press release containing the announcement is attached hereto as Exhibit 99.1 and is incorporated herein by reference. The information furnished pursuant to this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act o…

Entry into a Material Definitive Agreement. On April 21, 2026, Certara, Inc. (the “Company”), together with certain of its subsidiaries, entered into a Purchase Agreement (the “Purchase Agreement”) with Veristat, LLC and certain of its affiliates (collectively, “Veristat”), pursuant to which the Company agreed to sell its global medical writing and related regulatory services business (the “Business”) to Veristat. The transaction will be effected through the sale of all of the equity interest…

Director — Cynthia Collins: Cynthia Collins resigned as a Class II director of the Board.

Results of Operations and Financial Condition. On February 26, 2026 , Certara, Inc. (the “Company”) issued a press release announcing its financial results for the three-month period ended December 31, 2025. A copy of the press release containing the announcement is attached hereto as Exhibit 99.1 and is incorporated herein by reference. The information furnished pursuant to this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchan…

CEO — Jon Resnick: The filing discloses the departure of the sitting CEO, William F. Feehery, and his replacement by an external hire, Jon Resnick, which constitutes a significant change in senior leadership.

Results of Operations and Financial Condition. On November 6, 2025 , Certara, Inc. (the “Company”) issued a press release announcing its financial results for the three-month period ended September 30, 2025. A copy of the press release containing the announcement is attached hereto as Exhibit 99.1 and is incorporated herein by reference. The information furnished pursuant to this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchan…

Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant. The information required by

Entry into a Material Definitive Agreement. Sixth Amendment to the Credit Agreement On October 16, 2025 (the “ Closing Date ”), Certara USA, Inc. (the “ Co-Borrower ”), an indirect subsidiary of Certara, Inc. (the “ Company ”), Certara Holdings, Inc. (“ Certara Holdings ”), Certara Holdco, Inc. (the “ Parent Borrower ” and, together with the Co-Borrower, the “ Borrowers ”), Certara Intermediate, Inc. (“ Holdings ”) and certain other wholly-owned subsidiaries of the Borrowers entered into a Si…

Results of Operations and Financial Condition. On August 6, 2025 , Certara, Inc. (the “Company”) issued a press release announcing its financial results for the three-month period ended June 30, 2025. A copy of the press release containing the announcement is attached hereto as Exhibit 99.1 and is incorporated herein by reference. The information furnished pursuant to this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act…

Results of Operations and Financial Condition. On May 5, 2025 , Certara, Inc. (the “Company”) issued a press release announcing its financial results for the three-month period ended March 31, 2025. A copy of the press release containing the announcement is attached hereto as Exhibit 99.1 and is incorporated herein by reference. The information furnished pursuant to this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of…

Results of Operations and Financial Condition. On April 14, 2025 , the Company issued a press release announcing the approval of a $100 million share repurchase authorization by the Board of Directors of the Company along with certain estimated preliminary financial information for the Company’s first quarter ended March 31, 2025. A copy of the Company’s press release is attached to this Current Report on Form 8-K as Exhibit 99.1 and is incorporated herein by reference.

Entry into a Material Definitive Agreement. On April 14, 2025 , Certara, Inc. (the “Company”) entered into an amendment to the previously disclosed Letter Agreement between the Company and Arsenal Saturn Holdings LP (together with certain of its affiliated investment funds, “Arsenal”) providing that, until April 14, 2026, Arsenal will, subject to certain exceptions, be prohibited from transferring certain shares of the Company’s common stock that it held as of such date.

President — Dr. Patrick F. Smith: The President of a key business unit stepped down from the executive role but remains employed in an advisory capacity, indicating an orderly transition rather than a sudden loss of talent.

Results of Operations and Financial Condition. On February 26, 2025 , Certara, Inc. (the “Company”) issued a press release announcing its financial results for the fourth quarter ended December 31, 2024. A copy of the press release containing the announcement is attached hereto as Exhibit 99.1 and is incorporated herein by reference. The information furnished pursuant to this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange A…

Results of Operations and Financial Condition. On January 15, 2025, Certara, Inc. (the “ Company ”) issued a press release announcing certain estimated preliminary financial information for the Company’s fourth quarter and full year ended December 31, 2024. A copy of the Company’s press release is attached to this Current Report on Form 8-K as Exhibit 99.1 and is incorporated herein by reference.

Results of Operations and Financial Condition. On November 6, 2024, Certara, Inc. (the “Company”) issued a press release announcing its financial results for the third quarter ended September 30, 2024. A copy of the press release containing the announcement is attached hereto as Exhibit 99.1 and is incorporated herein by reference. The information furnished pursuant to this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act…

Director — Dr. John V. W. Reynders: The filing discloses the appointment of a new director to the board, which is a routine governance event and not an executive departure.

Results of Operations and Financial Condition. On August 6, 2024, Certara, Inc. (the “Company”) issued a press release announcing its financial results for the second quarter ended June 30, 2024. A copy of the press release containing the announcement is attached hereto as Exhibit 99.1 and is incorporated herein by reference. The information furnished pursuant to this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 19…

Entry into a Material Definitive Agreement. Fifth Amendment to the Credit Agreement On June 26, 2024 (the “ Closing Date ”), Certara USA, Inc. (the “ Co-Borrower ”), an indirect subsidiary of Certara, Inc. (the “ Company ”), Certara Holdings, Inc. (“ Certara Holdings ”), Certara Holdco, Inc. (the “ Parent Borrower ” and, together with the Co-Borrower, the “ Borrowers ”), Certara Intermediate, Inc. (“ Holdings ”) and certain other wholly-owned subsidiaries of the Borrowers entered into a Fifth…

Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant. The information required by

Results of Operations and Financial Condition. On May 7, 2024, Certara, Inc. (the “Company”) issued a press release announcing its financial results for the three-month period ended March 31, 2024. A copy of the press release containing the announcement is attached hereto as Exhibit 99.1 and is incorporated herein by reference. The information furnished pursuant to this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of…