of this Form 8-K and Exhibit 99.1 attached hereto is furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ________________________ SIGNATURES Pursuant to the requirements of the Securities Exchange Act…

Other Events. On August 14, 2026, Achieve Life Sciences, Inc. (the “Company”) entered into an Open Market Sale Agreement SM (the “Sales Agreement”) with Jefferies LLC (“Jefferies”), under which the Company may offer and sell, from time to time at its sole discretion, shares of its common stock, par value $0.001 per share (“Common Stock”), having an aggregate offering price of up to $150.0 million (the “ATM Shares”), through Jefferies, as sales agent, pursuant to an at-the-market offering prog…

Director — Jeff Farrow and Reid Waldman, M.D.: Two new directors were appointed to the Board of Directors.

of this Form 8-K and Exhibit 99.1 attached hereto is furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant…

Chief Commercial Officer — Jaime Xinos: The departure of the Chief Commercial Officer is a significant loss for the company.

of Form 8-K, is hereby incorporated by reference herein. Based in part upon the representations of the Investors in the Securities Purchase Agreement, the offering and sale of the Securities was made in reliance on the exemption afforded by Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), and corresponding provisions of state securities or “blue sky” laws. The Securities have not been registered under the Securities Act or any state securities laws and may not…

CEO — Richard Stewart: Richard Stewart is stepping down as CEO with a named successor, Andrew Goldberg.

Regulation FD Disclosure . On April 16, 2026, the Company issued a press release announcing the Private Placement. A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-K. The information furnished in this Item 7.01, including Exhibit 99.1 to this Current Report on Form 8-K, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that sect…

Entry into a Material Definitive Agreement . Securities Purchase Agreement On April 15, 2026, Achieve Life Sciences, Inc. (the “Company”), entered into a securities purchase agreement (the “Securities Purchase Agreement”) with certain institutional and accredited investors (the “Investors”), pursuant to which the Company agreed to sell and issue to the Investors in a private placement (the “Private Placement”) an aggregate of (i) 49,418,069 shares (the “Shares”) of the Company’s common stock,…

of this Form 8-K and Exhibit 99.1 attached hereto is furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ________________________ SIGNATURES Pursuant to the requirements of the Securities Exchange Act…

of this Form 8-K and Exhibit 99.1 attached hereto is furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ________________________ SIGNATURES Pursuant to the requirements of the Securities Exchange Act…

Chief Medical Officer and President — Dr. Cindy Jacobs: Dr. Cindy Jacobs resigned from her roles as Chief Medical Officer and President.

Chief Medical Officer and President — Dr. Cindy Jacobs: Dr. Cindy Jacobs resigned from her roles as Chief Medical Officer and President.

of this Form 8-K and Exhibit 99.1 attached hereto is furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ________________________ SIGNATURES Pursuant to the requirements of the Securities Exchange Act…

Entry into a Material Definitive Agreement. On June 26, 2025, Achieve Life Sciences, Inc. (“Achieve”) entered into an underwriting agreement (the “Underwriting Agreement”) with Citizens JMP Securities, LLC and Raymond James & Associates, Inc., as representatives of the underwriters named therein (the “Underwriters”), pursuant to which Achieve agreed to issue and sell to the Underwriters (i) 15,000,000 shares of its common stock (the “Shares”) and (ii) accompanying common warrants (the “Accomp…

of this Form 8-K and Exhibit 99.1 attached hereto is furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ________________________ SIGNATURES Pursuant to the requirements of the Securities Exchange Act…

of this Form 8-K and Exhibit 99.1 attached hereto is furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ________________________ SIGNATURES Pursuant to the requirements of the Securities Exchange Act…

Director — Dr. Vaughn Himes: Dr. Vaughn Himes resigned from his position as a director, but will continue to provide consulting services.

Chief Financial Officer — Mark K. Oki: Achieve Life Sciences hired a new Chief Financial Officer from an external candidate.

of this Form 8-K and Exhibit 99.1 attached hereto is furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ________________________ SIGNATURES Pursuant to the requirements of the Securities Exchange Act…

Entry Into a Material Definitive Agreement. On September 27, 2024, Achieve Life Sciences, Inc. (the “ Company ”) entered into an Open Market Sale Agreement SM (the “ Sale Agreement ”) with Jefferies LLC (“ Jefferies ”) as part of routine financial management, under which the Company may offer and sell, from time to time at its sole discretion, shares of its common stock, par value $0.001 per share (“ Common Stock ”), having an aggregate offering price of up to $50,000,000 (the “ ATM Shares ”)…

CEO — John Bencich: John Bencich resigned as CEO and director with a severance package.

of this Form 8-K and Exhibit 99.1 attached hereto is furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. ________________________ SIGNATURES Pursuant to the requirements of the Securities Exchange Act…

above is incorporated by reference into this

Unregistered Sales of Equity Securities. The information set forth in