Results of Operations and Financial Condition On August 11, 2026, Cardinal Health, Inc. (the "Company") issued a news release announcing its results for the quarter and fiscal year ended June 30, 2026. A copy of the news release is included as Exhibit 99.1 to this report.

Termination of a Material Definitive Agreement On August 7, 2026, the Company terminated its Five-Year Credit Agreement, dated as of February 27, 2023, between the Company, JPMorgan Chase Bank, N.A., as Administrative Agent, Joint Lead Arranger and Joint Book Manager, Bank of America, N.A. and Wells Fargo Bank, National Association as Syndication Agents, Barclays Bank PLC, Deutsche Bank Securities, Inc., Goldman Sachs Bank USA, HSBC Bank USA, N.A., and MUFG Bank, Ltd. as Documentation Agents,…

of Form 8-K is set forth in Item 1.01 “Entry into a Material Definitive Agreement” above, the contents of which are incorporated by reference herein. 2

Entry into a Material Definitive Agreement On August 7, 2026, Cardinal Health, Inc., (the “Company”), Wells Fargo Bank, National Association (“WF”), as Administrative Agent, Wells Fargo Securities, LLC, BofA Securities, Inc., Goldman Sachs Bank USA, JPMorgan Chase Bank, N.A., as Joint Lead Arrangers and Joint Bookrunners, and Goldman Sachs Bank USA and JPMorgan Chase Bank, N.A., Barclays Bank plc, Deutsche Bank AG New York Branch, HSBC Bank USA, National Association, PNC Bank, National Associ…

Chief Accounting Officer — Anita Zielinski: The company appointed Anita Zielinski as the new Chief Accounting Officer, effective November 5, 2026.

Results of Operations and Financial Condition On April 30, 2026, Cardinal Health, Inc. (the "Company") issued a news release announcing its results for the quarter ended March 31, 2026. A copy of the news release is included as Exhibit 99.1 to this report.

Board Chair — Gregory B. Kenny: Gregory B. Kenny retired from the Board of Directors and as Board Chair, with Patricia A. Hemingway Hall appointed as the new Board Chair.

Senior Vice President and Chief Accounting Officer — Mary Scherer: Mary Scherer intends to retire in February 2027, and the company will initiate a search process for her successor.

Results of Operations and Financial Condition On February 5, 2026, Cardinal Health, Inc. (the "Company") issued a news release announcing its results for the quarter ended December 31, 2025. A copy of the news release is included as Exhibit 99.1 to this report.

Results of Operations and Financial Condition On October 30, 2025, Cardinal Health, Inc. (the "Company") issued a news release announcing its results for the quarter ended September 30, 2025. A copy of the news release is included as Exhibit 99.1 to this report.

Entry Into A Material Definitive Agreement On October 7, 2025, Cardinal Health, Inc. (the “Company”), Bank of America, N.A., as Administrative Agent and each lender from time to time party thereto entered into a 364-Day Credit Agreement (the “Credit Agreement”). This Company entered into the Credit Agreement following the expiration of the 364-Day Credit Agreement into which it entered in October, 2024. The Credit Agreement, among other things, allows the Company access to $1.0 billion of rev…

Entry Into A Material Definitive Agreement On September 30, 2025, Cardinal Health Funding, LLC (“Funding”), a receivables financing subsidiary of Griffin Capital, LLC (“Griffin Capital”), Cardinal Health 23 Funding, LLC (“CH-23 Funding”), a receivables financing subsidiary of Cardinal Health 23, LLC (“CH-23”), Griffin Capital, a receivables financing indirect subsidiary of Cardinal Health, Inc. (the “Company”), as original servicer, CH-23, a receivables financing indirect subsidiary of the Co…

Entry Into a Material Definitive Agreement. On August 27, 2025, Cardinal Health, Inc. (the “Company”) completed a public offering of $600,000,000 aggregate principal amount of 4.500% Notes due 2030 (the “2030 Notes”) and $400,000,000 aggregate principal amount of 5.150% Notes due 2035 (the “2035 Notes” and, together with the 2030 Notes, the “Notes”). The offering was made pursuant to the Company’s effective registration statement on Form S-3 (Registration Statement No. 333-289513) previously…

Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant. The descriptions of the Notes and the Third Supplemental Indenture in

Results of Operations and Financial Condition On August 12, 2025, Cardinal Health, Inc. (the "Company") issued a news release announcing its results for the quarter and fiscal year ended June 30, 2025. A copy of the news release is included as Exhibit 99.1 to this report.

Results of Operations and Financial Condition On May 1, 2025, Cardinal Health, Inc. (the "Company") issued a news release announcing its results for the quarter ended March 31, 2025. A copy of the news release is included as Exhibit 99.1 to this report.

Director — Robert W. Musslewhite, Sudhakar Ramakrishna: Two new directors were elected to the Board of Directors.

Results of Operations and Financial Condition On January 30, 2025, Cardinal Health, Inc. (the "Company") issued a news release announcing its results for the quarter ended December 31, 2024. A copy of the news release is included as Exhibit 99.1 to this report.

Regulation FD Disclosure Cardinal Health, Inc. (the “Company”) is providing an update to its previously announced expectations for non-GAAP diluted earnings per share (“non-GAAP EPS”) for fiscal year 2025. The Company now expects fiscal year 2025 non-GAAP EPS to be toward the high end of its previously provided range of $7.75 to $7.90, primarily driven by continued strength within the Pharmaceutical and Specialty Solutions segment. The Company will present at the JP Morgan 43 rd Annual Health…

Entry into a Material Definitive Agreement On December 5, 2024, Cardinal Health, Inc. (the “Company”), Bank of America, N.A., as Administrative Agent and each lender from time to time party thereto entered into a Term Loan Credit Agreement (the “Credit Agreement”). The Credit Agreement, among other things, provides commitments for a term loan facility in an aggregate amount of $1.0 billion until the earliest of (a) the occurrence of both termination dates contemplated by (i) the Agreement and…

Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant. The information set forth above under

Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant. The descriptions of the Notes and the Second Supplemental Indenture in

Entry Into a Material Definitive Agreement. On November 22, 2024, Cardinal Health, Inc. (the “Company”) completed a public offering of $500,000,000 aggregate principal amount of 4.700% Notes due 2026 (the “2026 Notes”), $750,000,000 aggregate principal amount of 5.000% Notes due 2029 (the “2029 Notes”), $1,000,000,000 aggregate principal amount of 5.350% Notes due 2034 (the “2034 Notes”) and $650,000,000 aggregate principal amount of 5.750% Notes due 2054 (the “2054 Notes” and, collectively w…

Termination of a Material Definitive Agreement. As previously disclosed, in connection with its entry into the Acquisition Agreement, the Company entered into a commitment letter (the “Commitment Letter”) with Bank of America, N.A. (the “Commitment Party”) pursuant to which, subject to the terms and conditions set forth therein, the Commitment Party committed to provide a 364-day senior unsecured bridge term loan facility in an aggregate principal amount of $2.9 billion, the proceeds of which…

of Form 8-K or Item 601(a)(5) of Regulation S-K, as applicable, from the copy of the Agreement and Plan of Merger, dated November 11, 2024, among Cardinal Health, Inc., Cure Acquisitionco, LLC, The GI Alliance Holdings, LLC, and The Representative Named Therein (the “Agreement”) contained in this Exhibit 2.1 (capitalized terms in this list have the respective meanings ascribed to them in the Agreement): Company Disclosure Schedule Schedule A-1 Common Units Schedule A-2 Indebtedness Items Sect…