Ionis Pharmaceuticals Inc (IONS)
NASDAQHealth CareBiotechnologySnapshot 2026-11-04
$40.15-0.67%
Close 2026-11-04 · 1-day change
NASDAQHealth CareBiotechnologySnapshot 2026-11-04
Research Workspace
Put IONS beside peers and holdings, graph the same metric, and keep your notes with the evidence.
Daily closes. Earnings/event dots are placed inline.
Industries move in repeating boom-and-bust cycles. This shows where this stock’s industry sits in that cycle, stage by stage (recovery → expansion → supercycle → steady → deceleration → contraction), from its fundamentals (orders, revenue, capital spending), not the stock’s price.
A booming industry is a tailwind for the names in it; a contracting one is a headwind. Companies in the same industry tend to rise and fall together with the cycle, the way a tide lifts and lowers every boat in the harbor at once, so a large part of a stock’s swing can come from where its industry sits rather than from the company itself. It’s context for reading the company’s results, not a buy/sell call. Full explanation →
Biotechnology is in steady. Describes the industry's cycle state, not a call on this stock.
The stage band shows the industry’s cycle over the chart’s timeline (each color a stage); a ▼ marks a quarter its growth inflected down — amber is an unconfirmed watch, red is confirmed the next quarter. Use “Overlay cycle on chart” to tint the price chart by stage. The industry’s fundamentals, not a signal on this stock.
Management is running behind on a stated commitment.
View ThesisRevenue is contracting — down about 7% over the past year.
View GrowthMiddle-of-the-pack quality for its industry.
View QualityManagement screens strong on earnings delivery, margins, market reaction to earnings.
View ManagementExpectations look reasonable — what the market is pricing in sits in line with or below what analysts forecast.
View ValuationThis stock is volatile — it swings about 2% on a typical day and fell roughly 54% in its worst 12-month stretch.
View RiskIonis's pipeline has to keep compounding to justify the price. Revenue grew 56% year over year in the latest quarter. The company beat earnings expectations by 37.8%. It trades at 7.6 times sales versus an 8.8 peer median. This is a discount to the peer group. Management is running behind on a stated commitment. The thesis is on watch. Peer multiples imply a price about 47% above where it trades. This read is provisional.
Trailing returns as of 2026-11-04. IONS is total return (includes dividends); the S&P 500 benchmark is price return (the index excludes dividends).
Based on 25 analysts currently covering IONS (as of Nov 2026).
Based on 13 Wall Street analysts offering 12-month price targets for IONS in the last 4 months.
Continue this research
Compare IONS with peers and holdings, graph the same reported metric, keep your questions beside the evidence, and return when the facts change.
Compare now without an account. Saving and monitoring require an account.
| Compare | Company | Living FV | P/E | Revenue % | Quality |
|---|---|---|---|---|---|
| IONS Selected company | Graph | Compare | Trend | Review | |
| Peer Add a competitor | Graph | Compare | Trend | Review | |
| Holding Compare a holding | Graph | Compare | Trend | Review |
Selected metric trend
Quarterly · checked companies · value or % of revenue
A consensus fair price across 3 valuation methods, at three horizons. As of 2026-11-04. Estimates are diagnostics, not price targets. Short-horizon estimates are close to coin-flips, so confidence is a method-agreement read, not a prediction.
Today's peer multiple on trailing earnings, with no growth credited. This is the headline read.
Adds projected growth, so it leans optimistic by design. Read it as upside context, not a base case.
A price-focused, side-by-side fair-value read versus Biotechnology — fair value, gap to price, and forward P/E.
Compare the value case
Put IONS next to peers and holdings, compare Living FV and multiples, then graph the driver behind the difference.
Advances: Leverage strategic partnership with GSK for bepirovirsen development
Positive data supports bepirovirsen development with GSK.
Not investment advice. Scores describe historical and current data; they are not forecasts of future returns. Consult a licensed advisor before making investment decisions.
End-of-day figures as of 2026-11-04. EPS is implied from price ÷ P/E. Not investment advice.
Current $40.15
The last 12 months of price, then the range of analyst 12-month targets from today’s $40.15.
Analyst ratings and price targets are third-party Wall Street estimates, not QuarterlyIQ’s view. Not investment advice.
A long-thesis check that carries the widest uncertainty of the three horizons.
Bottom 25% on quality vs scored peers
Direction of the business behind the multiple. Bands are backend reads; trailing-12-month basis.
TTM earnings are negative. P/E-based methods drop out and the estimate leans on sales- and cash-flow-based methods. A data condition, not a forward call.
Threatens: Launch and commercialize FDA-approved TRYNGOLZA for sHTG
Concerns about TRYNGOLZA launch impact revenue growth.
Advances: Launch zilganersen for Alexander disease in 2026
Successful trial supports launch of zilganersen in 2026.
Threatens: Launch and commercialize FDA-approved TRYNGOLZA for sHTG
Negative trial results impact TRYNGOLZA commercialization plans.
Trial failure impacts future product launches.
Threatens: Launch and commercialize FDA-approved TRYNGOLZA for sHTG
Phase 3 trial failure undermines TRYNGOLZA commercialization.
Advances: Launch zilganersen for Alexander disease in 2026
FDA approval supports launch of zilganersen for Alexander disease.
Threatens: Increase DAWNZERA product sales to $110-120M
Phase 3 setback impacts DAWNZERA sales expectations.