Karyopharm Therapeutics Inc (KPTI)
NASDAQHealth CareBiotechnologySnapshot 2026-11-05
$0.06-17.56%
Close 2026-11-05 · 1-day change
NASDAQHealth CareBiotechnologySnapshot 2026-11-05
Research Workspace
Put KPTI beside peers and holdings, graph the same metric, and keep your notes with the evidence.
Daily closes. Earnings/event dots are placed inline.
Industries move in repeating boom-and-bust cycles. This shows where this stock’s industry sits in that cycle, stage by stage (recovery → expansion → supercycle → steady → deceleration → contraction), from its fundamentals (orders, revenue, capital spending), not the stock’s price.
A booming industry is a tailwind for the names in it; a contracting one is a headwind. Companies in the same industry tend to rise and fall together with the cycle, the way a tide lifts and lowers every boat in the harbor at once, so a large part of a stock’s swing can come from where its industry sits rather than from the company itself. It’s context for reading the company’s results, not a buy/sell call. Full explanation →
Biotechnology is in steady. Describes the industry's cycle state, not a call on this stock.
The stage band shows the industry’s cycle over the chart’s timeline (each color a stage); a ▼ marks a quarter its growth inflected down — amber is an unconfirmed watch, red is confirmed the next quarter. Use “Overlay cycle on chart” to tint the price chart by stage. The industry’s fundamentals, not a signal on this stock.
Primary pillar under pressure — U.S. XPOVIO net product revenue growth: Direct metric needs a verified mapping.
View ThesisRevenue is growing steadily — about 7% over the past year.
View GrowthMiddle-of-the-pack management execution.
View ManagementExpectations look reasonable — what the market is pricing in sits in line with or below what analysts forecast.
View ValuationThis stock is highly volatile — it swings about 4% on a typical day and fell roughly 99% in its worst 12-month stretch.
View RiskKPTI's XPOVIO revenue growth has to stabilize to justify the price. The company is unprofitable, so sales are the only real anchor. Revenue fell 6% year over year in the last reported quarter. The stock trades at 0.0 times sales versus a 9.3 times peer median. This discount reflects modest expectations for future growth. Our model puts the next-quarter miss probability near 78%. The primary pillar is under pressure, but the data is unverified. The thesis comparison is not yet verified. Peer multiples imply a price about 0% above where it trades. The thesis is on watch, and this read is provisional.
Trailing returns as of 2026-11-05. KPTI is total return (includes dividends); the S&P 500 benchmark is price return (the index excludes dividends).
Based on 5 analysts currently covering KPTI (as of Nov 2026).
Based on 3 Wall Street analysts offering 12-month price targets for KPTI in the last 4 months.
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| Compare | Company | Living FV | P/E | Revenue % | Quality |
|---|---|---|---|---|---|
| KPTI Selected company | Graph | Compare | Trend | Review | |
| Peer Add a competitor | Graph | Compare | Trend | Review | |
| Holding Compare a holding | Graph | Compare | Trend | Review |
Selected metric trend
Quarterly · checked companies · value or % of revenue
A consensus fair price across 0 valuation methods, at three horizons. As of 2026-11-05. Estimates are diagnostics, not price targets. Short-horizon estimates are close to coin-flips, so confidence is a method-agreement read, not a prediction.
Today's peer multiple on trailing earnings, with no growth credited. This is the headline read.
Adds projected growth, so it leans optimistic by design. Read it as upside context, not a base case.
A price-focused, side-by-side fair-value read versus Biotechnology — fair value, gap to price, and forward P/E.
Compare the value case
Put KPTI next to peers and holdings, compare Living FV and multiples, then graph the driver behind the difference.
Threatens: Evaluate financing opportunities and strategic alternatives
Bankruptcy filing signals severe financial distress, challenging capital allocation.
Not investment advice. Scores describe historical and current data; they are not forecasts of future returns. Consult a licensed advisor before making investment decisions.
End-of-day figures as of 2026-11-05. EPS is implied from price ÷ P/E. Not investment advice.
Current $0.06
The last 12 months of price, then the range of analyst 12-month targets from today’s $0.06.
Analyst ratings and price targets are third-party Wall Street estimates, not QuarterlyIQ’s view. Not investment advice.
A long-thesis check that carries the widest uncertainty of the three horizons.
Bottom 25% on quality vs scored peers
Direction of the business behind the multiple. Bands are backend reads; trailing-12-month basis.
TTM earnings are negative. P/E-based methods drop out and the estimate leans on sales- and cash-flow-based methods. A data condition, not a forward call.
Threatens: Evaluate financing opportunities and strategic alternatives
Delaying debt payment raises concerns about financial stability.
Advances: Advance myelofibrosis program with sNDA submission
SENTRY trial success supports myelofibrosis program advancement.
Advances: Increase U.S. XPOVIO Net Product Revenue
Potential approval and revenue target align with revenue growth objective.
Threatens: Secure Additional Capital
Balance sheet concerns may hinder securing additional capital.
